N SEDDIGHI; MB ARDESHIR LARIJANI; S SHARGHI; R HESHMAT; P SHOUSHTARIZADEH; V HAGHPANAH; B RAJABI POUR; A LASHKARI
Volume 13, Issue 3 , September and October 2006, , Pages 116-121
Abstract
Background and Purpose: Serum soluble Fas (sFas) is found in low concentrations in the sera of healthy subjects and it elevated in patients with autoimmune diseases, malignancy and inflammatory diseases. The Fas molecules play some role in the pathogenesis of Graves’ disease through interfering with ...
Read More
Background and Purpose: Serum soluble Fas (sFas) is found in low concentrations in the sera of healthy subjects and it elevated in patients with autoimmune diseases, malignancy and inflammatory diseases. The Fas molecules play some role in the pathogenesis of Graves’ disease through interfering with the Fas-FasL interaction. Therefore, this study was conducted to evaluate the relationship between soluble Fas serum level and thyroid autoantibodies.
Methods and Materials: In order to determine the association of serum sFas level with thyroid autoantibodies, we evaluated the serum levels of sFas and thyroid antibodies in 31 untreated GD patients and 37 respective healthy controls.
Results: sFas serum level was reported to be higher in patients than in healthy subjects (P
MB ARDESHIR LARIJANI; M MOTASADDI; H HADIZADEH; A FARD ESFAHANIAN; R HESHMAT; O TABATABAEI; S SHARGHI; V HAGHPANAH; E TAHERI; A LASHKARI
Volume 13, Issue 1 , March and April 2006, , Pages 33-39
Abstract
Background and purpose: Pendred syndrome, defined traditionally as the constellation of goiter, sensori-neural hearing loss and positive perchlorate discharge test. Since the relatively newer approaches to the diagnosis of this syndrome, as MRI and genetic and/or molecular analysis are much more expensive ...
Read More
Background and purpose: Pendred syndrome, defined traditionally as the constellation of goiter, sensori-neural hearing loss and positive perchlorate discharge test. Since the relatively newer approaches to the diagnosis of this syndrome, as MRI and genetic and/or molecular analysis are much more expensive and complicated than the traditional approaches, we planned to study the value and reliability of MRI as the sole, or adjunctive diagnostic approach to the syndrome. Materials and methods: We presumed the classic triad is still the most widely accepted gold standard, and compared MRI findings in six such defined patients with six seemingly incomplete forms with goiter and hearing loss, but with negative Perchlorate discharge test.
Results: There were a sensitivity and specificity of 83.3% and 66.7%, respectively for MRI in patients fulfilling all three criteria and 66.7% and 100% for sensitivity and specificity in the group lacking perchlorate test positivity. Conclusion: Although MRI can not replace the holistic approach, In "partial" cases with equivocal findings, and in the evaluation of relatives of the patients MRI may be considered as a valuable diagnostic adjunct.